HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Anisoyl chloride → HCID 67715594, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Anisoyl chloride | HCID 7477 | — |
| Reactant | 5,11-dihydro-11-[[4-[3-(ethylamino)propyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 19039412 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67715594 | HCID 67715594 | 81% |
Reaction Steps
Prepared analogously to Example 1 from 5,11-dihydro-11-[[4-[3-(ethylamino)propyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 4-methoxybenzoic acid chloride. The free base is dissolved in ethyl acetate and the dihydrochloride is precipitated by the addition of ethereal hydrochloric acid. The desired compound is obtained in a yield of 81% by recrystallisation from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05641772 |
| Source dataset | uspto-grants-1997_06 |
| ORD ID | ord-bd456e3d9d024f718225003597e6c8f4 |
| Source note | uspto-grants-1997_06 |