HRID1684510

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7477

Benzoyl chloride, 4-methoxy-

C8H7ClO2

结构：CCNCCCC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1

HCID19039412

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(=O)CCNCCCC2CCN(CC(=O)N3c4ccccc4C(=O)Nc4cccnc43)CC2)cc1.Cl.Cl

HCID67715594

未命名化合物

收率 81%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Prepared analogously to Example 1 from 5,11-dihydro-11-[[4-[3-(ethylamino)propyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 4-methoxybenzoic acid chloride. The free base is dissolved in ethyl acetate and the dihydrochloride is precipitated by the addition of ethereal hydrochloric acid. The desired compound is obtained in a yield of 81% by recrystallisation from ethanol.

WORKUP

后处理

customthe dihydrochloride is precipitated by the addition of ethereal hydrochloric acid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bd456e3d9d024f718225003597e6c8f4
来源数据集: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05641772
来源说明: uspto-grants-1997_06

反应 SMILES

[CH2:1]([NH:3][CH2:4][CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]([N:16]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[C:20](=[O:27])[NH:19][C:18]3[CH:28]=[CH:29][CH:30]=[N:31][C:17]2=3)=[O:15])[CH2:9][CH2:8]1)[CH3:2].[CH3:32][O:33][C:34]1[CH:42]=[CH:41][C:37]([C:38]([Cl:40])=[O:39])=[CH:36][CH:35]=1>C(OCC)(=O)C>[ClH:40].[ClH:40].[CH3:32][O:33][C:34]1[CH:42]=[CH:41][C:37]([C:38]([CH2:2][CH2:1][NH:3][CH2:4][CH2:5][CH2:6][CH:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]([N:16]3[C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=4[C:20](=[O:27])[NH:19][C:18]4[CH:28]=[CH:29][CH:30]=[N:31][C:17]3=4)=[O:15])[CH2:9][CH2:8]2)=[O:39])=[CH:36][CH:35]=1