11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one → HCID 19039393, compound

HRID 1684513Notes

Reaction equation

HRID 1684513 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[N:20][C:6]1=2)=[O:4].[C:21]([CH2:24][NH:25][CH2:26][CH2:27][CH2:28][CH:29]1[CH2:34][CH2:33][CH2:32][NH:31][CH2:30]1)(=[O:23])[CH3:22]>>[C:21]([CH2:24][NH:25][CH2:26][CH2:27][CH2:28][CH:29]1[CH2:34][CH2:33][CH2:32][N:31]([CH2:2][C:3]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9](=[O:16])[NH:8][C:7]3[CH:17]=[CH:18][CH:19]=[N:20][C:6]2=3)=[O:4])[CH2:30]1)(=[O:23])[CH3:22]

Participants

3

Reactant 2

HCID 12005311-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 19039423HCID 19039423, compound

Product 1

HCID 19039393HCID 19039393, compound

Procedure

Prepared analogously to Example 8 from 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one and 3-[3-[(acetyl)methylamino]-propyl]piperidine. Purification is carried out by chromatography on silica gel (Baker) using methylene chloride to which increasing amounts of methanol are added.

Workup

  1. customPurification
  2. temperatureincreasing amounts of methanol
  3. additionare added

Sources & evidence

ORD record
ord-6d99d7b7eebf48659965092c76dcf594
Source dataset
uspto-grants-1997_06
Patent number
US05641772

Reaction notes

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