Dichloromethane → 2-[(4-tert-butylbenzyl)amino]-1-(5-isoquinolinyl)-2-oxoethyl Acetate

HRID 168474Notes

Reaction equation

HRID 168474 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]([CH2:9][NH:10][C:11]([CH:12]([c:13]2[c:14]3[cH:15][cH:16][n:17][cH:18][c:19]3[cH:20][cH:21][cH:22]2)[OH:23])=[O:24])[cH:25][cH:26]1.[CH3:27][C:28](=[O:29])[O:30][C:31](=[O:32])[CH3:33].[CH3:34][N:35]([c:36]1[cH:37][cH:38][n:39][cH:40][cH:41]1)[CH3:42].[Cl:43][CH2:44][Cl:45]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]([CH2:9][NH:10][C:11]([CH:12]([c:13]2[c:14]3[cH:15][cH:16][n:17][cH:18][c:19]3[cH:20][cH:21][cH:22]2)[O:23][C:28]([CH3:27])=[O:29])=[O:24])[cH:25][cH:26]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 7918Acetic AnhydrideHCID 142844-(Dimethylamino)pyridineHCID 11291000N-(4-tert-butylbenzyl)-2-hydroxy-2-(5-isoquinolinyl)acetamide

Product 1

HCID 574338442-[(4-tert-butylbenzyl)amino]-1-(5-isoquinolinyl)-2-oxoethyl Acetate

Sources & evidence

ORD record
ord-d79e702b6fce44edadd545903c0c5fbb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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