Hydrochloric Acid → HCID 69646560, compound

HRID 1684747Notes

Reaction equation

HRID 1684747 reaction equation
C(OC([NH:8][C@H:9]([C@@H:31]([OH:42])[CH2:32][C@H:33]([C:35](=[O:41])[NH:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH3:34])[CH2:10][C@@H:11]([CH:28]([CH3:30])[CH3:29])[CH2:12][NH:13][C:14](=[O:27])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[O:21][CH2:22][CH2:23][CH2:24][O:25][CH3:26])=O)(C)(C)C.[ClH:43]>O1CCOCC1>[ClH:43].[NH2:8][C@H:9]([C@@H:31]([OH:42])[CH2:32][C@H:33]([C:35](=[O:41])[NH:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH3:34])[CH2:10][C@@H:11]([CH:28]([CH3:30])[CH3:29])[CH2:12][NH:13][C:14](=[O:27])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[O:21][CH2:22][CH2:23][CH2:24][O:25][CH3:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57092462HCID 57092462, compound

Product 1

HCID 69646560HCID 69646560, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
0 °C

Procedure

(2S,4S,5S,7R)-N-[4-(tert-Butoxycarbonyl)amino-7-butylcarbamoyl-5-hydroxy-2-isopropyl-octyl]-2-(3-methoxypropoxy)-benzamide (82 mg) is dissolved at 0° C. in 3 ml of a 4N hydrochloric acid solution in dioxane, and the solution is stirred at 0° C. for 2 hours. The reaction mixture is lyophilised and (2S,4S,5S,7R)-N-(4-amino-7-butylcarbamoyl-5-hydroxy-2-isopropyl-octyl)-2-(3-methoxypropoxy)-benzamide hydrochloride is obtained in the form of a white foam: Rf (L)=0.12. HPLC Rt =11.6 min. MS(FAB) m/e 494 (M+ +1).

Sources & evidence

ORD record
ord-57aad5a8fbc446c3a84c220a94e95e78
Source dataset
uspto-grants-1997_06
Patent number
US05641778

Reaction notes

Loading…