Hydrochloric Acid → HCID 69646260, compound

HRID 1684754Notes

Reaction equation

HRID 1684754 reaction equation
C(OC([NH:8][C@H:9]([C@@H:31]([OH:48])[CH2:32][C@H:33]([C:37](=[O:47])[NH:38][CH2:39][CH2:40][N:41]1[CH2:46][CH2:45][O:44][CH2:43][CH2:42]1)[CH:34]([CH3:36])[CH3:35])[CH2:10][C@@H:11]([CH:28]([CH3:30])[CH3:29])[CH2:12][NH:13][C:14](=[O:27])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[O:21][CH2:22][CH2:23][CH2:24][O:25][CH3:26])=O)(C)(C)C.[ClH:49]>O1CCOCC1>[ClH:49].[ClH:49].[NH2:8][C@H:9]([C@@H:31]([OH:48])[CH2:32][C@H:33]([C:37](=[O:47])[NH:38][CH2:39][CH2:40][N:41]1[CH2:46][CH2:45][O:44][CH2:43][CH2:42]1)[CH:34]([CH3:36])[CH3:35])[CH2:10][C@@H:11]([CH:28]([CH3:29])[CH3:30])[CH2:12][NH:13][C:14](=[O:27])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[O:21][CH2:22][CH2:23][CH2:24][O:25][CH3:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57208147HCID 57208147, compound

Product 1

HCID 69646260HCID 69646260, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(2S,4S,5S,7S)-N-[4-(tert-Butoxycarbonyl)amino-5-hydroxy-2-isopropyl-8-methyl-7-(2-morpholin-4-ylethylcarbamoyl)-nonyl]-2-(3-methoxypropoxy)-benzamide (64 mg) is stirred in 2 ml of a 4N hydrochloric acid solution in dioxane at 0° C. for one hour, in a manner analogous to that described in Example 21). Removal of the solvent and drying under a high vacuum yield (2S,4S,5S,7S)-N-[4-amino-5-hydroxy-2-isopropyl-8-methyl-7-(2-morpholin-4-ylethylcarbamoyl)-nonyl]-2-(3-methoxypropoxy)-benzamide dihydrochloride: Rf (W)=0.13. HPLC Rt =9.59 min. MS(FAB) m/e 579 (M+ +1).

Workup

  1. customRemoval of the solvent
  2. customdrying under a high vacuum

Sources & evidence

ORD record
ord-aca2e9c001ca4db8b4ba546f93006346
Source dataset
uspto-grants-1997_06
Patent number
US05641778

Reaction notes

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