Pyrrolidine → HCID 54433321, compound

HRID 1684758Notes

Reaction equation

HRID 1684758 reaction equation
[CH3:1][O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:5]=1[O:11][CH2:12][CH2:13][CH2:14][CH2:15][O:16][CH3:17].[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH3:1][O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[CH:6][C:5]=1[O:11][CH2:12][CH2:13][CH2:14][CH2:15][O:16][CH3:17]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 53730226HCID 53730226, compound

Product 1

HCID 54433321HCID 54433321, compound

Procedure

The 2-(4-methoxybutoxy)-4-(pyrrolidin-1-ylmethyl)-benzoic acid methyl ester that is used is prepared in a manner analogous to that described in Example 30Aa) from 2-(4-methoxybutoxy)-4-methyl-benzoic acid methyl ester and pyrrolidine, with subsequent purification of the crude product by FC (eluants C and M): brown-black oil, Rf (N)=0.22.

Workup

  1. customwith subsequent purification of the crude product by FC (eluants C and M)

Sources & evidence

ORD record
ord-e7c3b2d04235409b944ea16901866513
Source dataset
uspto-grants-1997_06
Patent number
US05641778

Reaction notes

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