Ethyl 3-(4-pyridyl)-3-oxopropionate → 2-(4-Oxo-2-pyrimidin-4-yl-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl)-isoindole-1,3-dione

HRID 1684900Notes

Reaction equation

HRID 1684900 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7](=O)[CH2:8][C:9]([O:11]CC)=O)=[N:3][CH:2]=1.N1C=CC(C(=O)CC(OCC)=O)=CC=1.[NH2:29][C:30]1[CH:34]([N:35]2[C:43](=[O:44])[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[C:36]2=[O:45])[CH2:33][CH2:32][N:31]=1>>[O:11]=[C:9]1[N:31]2[CH2:32][CH2:33][CH:34]([N:35]3[C:43](=[O:44])[C:42]4[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=4)[C:36]3=[O:45])[C:30]2=[N:29][C:7]([C:4]2[CH:5]=[CH:6][N:1]=[CH:2][N:3]=2)=[CH:8]1

Participants

4

Reactant 3

HCID 2735202Ethyl 3-(4-pyridyl)-3-oxopropionateHCID 11961458Ethyl 3-oxo-3-(pyrimidin-4-yl)propanoateHCID 672657232-(2-amino-4,5-dihydro-3H-pyrrol-3-yl)-isoindole-1,3-dione

Product 1

HCID 672659262-(4-Oxo-2-pyrimidin-4-yl-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl)-isoindole-1,3-dione

Procedure

By analogy with the method described in example 1 (step 1.3), using ethyl 3-(4-pyrimidinyl)-3-oxopropionate (prepared by analogy to the method described in patent DE 2705582) in place of ethyl 3-(pyridin-4-yl)-3-oxopropionate and using 2-(2-amino-4,5-dihydro-3H-pyrrol-3-yl)-isoindole-1,3-dione, the compound was obtained as a white powder.

Workup

  1. customprepared by analogy to the method
  2. customthe compound was obtained as a white powder

Sources & evidence

ORD record
ord-f74c9e0409ac4791a6c82c1e80c08094
Source dataset
uspto-grants-2012_04
Patent number
US08148364B2

Reaction notes

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