HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(4-pyridyl)-3-oxopropionate → 2-(4-Oxo-2-pyrimidin-4-yl-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl)-isoindole-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(4-pyridyl)-3-oxopropionate | HCID 2735202 | — |
| Reactant | Ethyl 3-oxo-3-(pyrimidin-4-yl)propanoate | HCID 11961458 | — |
| Reactant | 2-(2-amino-4,5-dihydro-3H-pyrrol-3-yl)-isoindole-1,3-dione | HCID 67265723 | — |
| Product | 2-(4-Oxo-2-pyrimidin-4-yl-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl)-isoindole-1,3-dione | HCID 67265926 | — |
Reaction Steps
By analogy with the method described in example 1 (step 1.3), using ethyl 3-(4-pyrimidinyl)-3-oxopropionate (prepared by analogy to the method described in patent DE 2705582) in place of ethyl 3-(pyridin-4-yl)-3-oxopropionate and using 2-(2-amino-4,5-dihydro-3H-pyrrol-3-yl)-isoindole-1,3-dione, the compound was obtained as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148364B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-f74c9e0409ac4791a6c82c1e80c08094 |
| Source note | uspto-grants-2012_04 |