Hydrochloric Acid → HCID 66623754, compound

HRID 1684912Notes

Reaction equation

HRID 1684912 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][C:13]([B:16]4[O:20]C(C)(C)C(C)(C)[O:17]4)=[CH:12][N:11]3[CH:25]=2)=[CH:4][CH:3]=1.Cl>CC(C)=O.O>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][C:13]([B:16]([OH:20])[OH:17])=[CH:12][N:11]3[CH:25]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 44232240HCID 44232240, compound

Product 1

HCID 66623754HCID 66623754, compoundYield 138.4%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

7.93 g of 2-(4-chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine are dissolved in 200 ml of acetone and 100 ml of water; 223 ml of 1N hydrochloric acid are added thereto, dropwise there with stirring, and the mixture is stirred at ambient temperature for 16 h. The reaction mixture is subsequently concentrated under reduced pressure. 4.78 g of compound are obtained, which compound is used as is in the following stages.

Workup

  1. stirringthe mixture is stirred at ambient temperature for 16 h
  2. concentrationThe reaction mixture is subsequently concentrated under reduced pressure

Sources & evidence

ORD record
ord-0207dd44f5d540b98e2a80c1a1e244c9
Source dataset
uspto-grants-2012_04
Patent number
US08148370B2

Reaction notes

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