Hydrochloric Acid → HCID 67265083, compound

HRID 1684917Notes

Reaction equation

HRID 1684917 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[C:11]3[CH:16]=[CH:15][C:14]([B:17]4[O:21]C(C)(C)C(C)(C)[O:18]4)=[CH:13][N:12]3[CH:26]=2)[CH:6]=[CH:7][CH:8]=1.[ClH:27]>CC(C)=O.O>[ClH:27].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[C:11]3[CH:16]=[CH:15][C:14]([B:17]([OH:21])[OH:18])=[CH:13][N:12]3[CH:26]=2)[CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67265133HCID 67265133, compound

Product 1

HCID 67265083HCID 67265083, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

7.47 g of 2-(3-methoxyphenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine are dissolved in 236 ml of acetone and 118 ml of water; 213 ml of 1N hydrochloric acid are added thereto, dropwise and with stirring, and the mixture is stirred at ambient temperature for 24 h. The reaction mixture is subsequently concentrated under reduced pressure. The solid obtained is triturated from diethyl ether, collected by filtration and then dried in an oven under reduced pressure at 60° C. 5.80 g of compound are obtained.

Workup

  1. stirringthe mixture is stirred at ambient temperature for 24 h
  2. concentrationThe reaction mixture is subsequently concentrated under reduced pressure
  3. customThe solid obtained
  4. customis triturated from diethyl ether
  5. filtrationcollected by filtration
  6. customdried in an oven under reduced pressure at 60° C

Sources & evidence

ORD record
ord-d1b5acc79ef449b786bf0bbd4a92d9ab
Source dataset
uspto-grants-2012_04
Patent number
US08148370B2

Reaction notes

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