反应详情

20 g of 3-bromo-2,6-difluorobenzaldehyde are dissolved in 450 ml of methanol and cooled in an ice bath; 3.42 g of sodium borohydride are then added portionwise thereto. The mixture is stirred at ambient temperature for 1 hour and then the solvent is evaporated under reduced pressure. The residue is taken up between water and dichloromethane and the organic phase is separated, dried and concentrated under reduced pressure. The residue is crystallised from n-pentane. 14.6 g of compound are obtained.

1. temperaturecooled in an ice bath
2. customthe solvent is evaporated under reduced pressure
3. customthe organic phase is separated
4. customdried
5. concentrationconcentrated under reduced pressure
6. customThe residue is crystallised from n-pentane