Sodium borohydride → (3-Bromo-2,6-difluorophenyl)methanol

HRID 1684925Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1684925
[Br:1][C:2]1[C:3]([F:11])=[C:4]([C:7]([F:10])=[CH:8][CH:9]=1)[CH:5]=[O:6].[BH4-].[Na+]>CO>[Br:1][C:2]1[C:3]([F:11])=[C:4]([CH2:5][OH:6])[C:7]([F:10])=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 221397013-Bromo-2,6-difluorobenzaldehyde

Produkt 1

HCID 22219889(3-Bromo-2,6-difluorophenyl)methanolAusbeute 72,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

20 g of 3-bromo-2,6-difluorobenzaldehyde are dissolved in 450 ml of methanol and cooled in an ice bath; 3.42 g of sodium borohydride are then added portionwise thereto. The mixture is stirred at ambient temperature for 1 hour and then the solvent is evaporated under reduced pressure. The residue is taken up between water and dichloromethane and the organic phase is separated, dried and concentrated under reduced pressure. The residue is crystallised from n-pentane. 14.6 g of compound are obtained.

Aufarbeitung

  1. temperaturecooled in an ice bath
  2. customthe solvent is evaporated under reduced pressure
  3. customthe organic phase is separated
  4. customdried
  5. concentrationconcentrated under reduced pressure
  6. customThe residue is crystallised from n-pentane

Quellen und Nachweise

ORD-Eintrag
ord-4b7cd46588334324b418e9a878fe6803
Quelldatensatz
uspto-grants-2012_04
Patentnummer
US08148370B2

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