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Dimethylformamide → HCID 24956665、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Cyclopropylamine | HCID 69828 | — |
| 反応物 | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| 反応物 | 2-phenyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid | HCID 22477635 | — |
| 生成物 | HCID 24956665 | HCID 24956665 | — |
反応手順
To a solution of compound B of this example (18 mg, 80% pure) in dimethyl formamide (1 mL) at RT were added BOP (40 mg) and cyclopropylamine (0.05 mL). After stirring for 30 min, the reaction mixture was purified by RP HPLC eluting with a mixture of methanol in water containing 0.1% TFA. The fractions containing the product were collected, concentrated, and neutralized with NaHCO3 solution. The solid obtained was filtered, washed with water, and dried in vacuo to afford the title compound (11 mg). LC/MS; (M+H)+=397.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08148361B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-62fdb193803343fc96b308d0e0f45666 |
| 出典メモ | uspto-grants-2012_04 |