Methylamine → HCID 25052051, compound

HRID 1685001Notes

Reaction equation

HRID 1685001 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15]Cl)[N:14]=1)=[O:8].[CH3:21][NH2:22]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][NH:22][CH3:21])[N:14]=1)=[O:8]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 58055096HCID 58055096, compound

Product 1

HCID 25052051HCID 25052051, compound

Procedure

A solution of 1-(3,4-dichlorobenzyl)-3-(4-(chloromethyl)thiazol-2-yl)urea and excess methylamine (2.0 M solution in tetrahydrofuran) was heated for 15 minutes at 60° C. under microwave irradiation. The volatiles were removed in vacuo and the product was purified by column chromatography (DCM/0-15% NH3 saturated MeOH) to afford the title compound.

Workup

  1. customThe volatiles were removed in vacuo
  2. customthe product was purified by column chromatography (DCM/0-15% NH3 saturated MeOH)

Sources & evidence

ORD record
ord-b8f41a4f2ee14dbbaf9f52f75f90404d
Source dataset
uspto-grants-2012_04
Patent number
US08148380B2

Reaction notes

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