反应详情

1-(3-Fluorobenzyl)-3-(4-(iodomethyl)thiazol-2-yl)urea (Intermediate 7) was taken up in tetrahydrofuran and an excess of the 2-amino-ethanol (20 equiv.) was added. The reaction was allowed to stir overnight at room temperature. The reaction was poured into water and extracted with EtOAc, partitioned with brine, dried over Na2SO4, filtered, and volatiles were removed in vacuo. The resulting solid was triturated with EtOAc, followed by diethyl ether to give the title compound.

1. extractionextracted with EtOAc
2. custompartitioned with brine
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. customvolatiles were removed in vacuo
6. customThe resulting solid was triturated with EtOAc