Hydrochloric Acid → 2-Amino-5-fluorothiazole dihydrochloride salt

HRID 1685050Notes

Reaction equation

HRID 1685050 reaction equation
C(OC([NH:8][C:9]1[S:10][C:11]([F:19])=[C:12](CN(OC)C)[N:13]=1)=O)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[NH2:8][C:9]1[S:10][C:11]([F:19])=[CH:12][N:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 580550492-(tert-butoxycarbonylamino)-4-(N-methoxy-N-methyl-aminomethyl)-5-fluorothiazole

Product 1

HCID 866613032-Amino-5-fluorothiazole dihydrochloride saltYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 2-(tert-butoxycarbonylamino)-4-(N-methoxy-N-methyl-aminomethyl)-5-fluorothiazole (3.6 g, 12.4 mmol) in 1,4-dioxane (60 mL) was saturated with dry HCl gas and held overnight. The mixture was evaporated to dryness to leave the 2-amino-5-fluorothiazole dihydrochloride salt (3.3 g, 100% yield).

Workup

  1. customThe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-be1fefd668674bd1b939952a68b83d98
Source dataset
uspto-grants-2012_04
Patent number
US08148380B2

Reaction notes

Loading…