Ethanol → Acetic acid 2-amino-thiazol-4-ylmethyl ester

HRID 1685052Notes

Reaction equation

HRID 1685052 reaction equation
Cl[CH2:2][C:3](=O)[CH2:4][OH:5].[NH2:7][C:8]([NH2:10])=[S:9].[CH3:11][CH2:12][OH:13]>>[NH2:7][C:8]1[S:9][CH:2]=[C:3]([CH2:4][O:5][C:12](=[O:13])[CH3:11])[N:10]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 904941-Chloro-3-hydroxy-2-propanoneHCID 2723790Thiourea

Product 1

HCID 21915033Acetic acid 2-amino-thiazol-4-ylmethyl ester

Procedure

1-Chloro-3-hydroxy-propan-2-one (15.06 g) and thiourea (8.36 g) were dissolved in EtOH (55 mL) and heated at reflux over 30 min. The reaction mixture was concentrated under reduced pressure to afford the desired product.

Workup

  1. temperatureheated
  2. temperatureat reflux over 30 min
  3. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-fa3d1f2b4e6948d5999f82786c304316
Source dataset
uspto-grants-2012_04
Patent number
US08148380B2

Reaction notes

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