HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3,6-Dichloropyridazine-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3,6-Dichloropyridazine-4-carboxylic acid | HCID 433804 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3,6-Dichloropyridazine-4-carbonyl chloride | HCID 81018 | — |
Reaction Steps
To a suspension of 3,6-dichloropyridazine-4-carboxylic acid (1.16 g, 6 mmol) in toluene (20 mL) were added DMF (2 drops) and SOCl2 (4 mL) and the mixture was heated at reflux temperature for 3 h. The volatiles were removed and the residue was stripped with toluene. The resulting brown oil (3,6-dichloropyridazine-4-carbonyl chloride) was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148380B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-b09902e606814bf5bdbf50f9eb90975c |
| Source note | uspto-grants-2012_04 |