Boron tribromide → HCID 178434137, compound

HRID 1685093Notes

Reaction equation

HRID 1685093 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][CH:31]=1)[CH2:5][NH:6][C:7](=[O:28])[NH:8][C:9]1[S:10][CH:11]=[C:12]([CH2:14][N:15]([CH3:27])[C:16]([C:18]2[CH:23]=[C:22]([O:24]C)[N:21]=[N:20][C:19]=2[CH3:26])=[O:17])[N:13]=1.B(Br)(Br)Br>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][CH:31]=1)[CH2:5][NH:6][C:7](=[O:28])[NH:8][C:9]1[S:10][CH:11]=[C:12]([CH2:14][N:15]([CH3:27])[C:16]([C:18]2[CH:23]=[C:22]([OH:24])[N:21]=[N:20][C:19]=2[CH3:26])=[O:17])[N:13]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 86661323HCID 86661323, compound

Product 1

HCID 178434137HCID 178434137, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6-Methoxy-3-methyl-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide was dissolved in DCM and treated with an excess of BBr3 at room temperature for a couple of hours. Column chromatography afforded the title product.

Sources & evidence

ORD record
ord-6d48ac31db6145629c55c299d69abae1
Source dataset
uspto-grants-2012_04
Patent number
US08148380B2

Reaction notes

Loading…