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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1685108Generated: October 31, 2026

Morpholine → 6-(Morpholin-4-yl)pyridin-2-amine

https://huagongshe.com/reaction/1685108

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
Reactant2-Amino-6-chloropyridineHCID 206246—
Product6-(Morpholin-4-yl)pyridin-2-amineHCID 18771860—

Reaction Conditions

Temperature225 °C

Reaction Steps

A mixture of 2-amino-6-chloropyridine in 100 mL of morpholine was heated at 225° C. for 60 mins. The mixture was cooled and precipitate filtered off, the filtrate was concentrated to give the 17 gram product as a brown oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08148367B2
Source datasetuspto-grants-2012_04
ORD IDord-5420d8f6d19e4bcf92b4bfd6b98332b2
Source noteuspto-grants-2012_04