Morpholine → 6-(Morpholin-4-yl)pyridin-2-amine

HRID 1685108Notes

Reaction equation

HRID 1685108 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>>[O:12]1[CH2:13][CH2:14][N:9]([C:4]2[N:3]=[C:2]([NH2:1])[CH:7]=[CH:6][CH:5]=2)[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 2062462-Amino-6-chloropyridine

Product 1

HCID 187718606-(Morpholin-4-yl)pyridin-2-amine

Conditions

Temperature
225 °C

Procedure

A mixture of 2-amino-6-chloropyridine in 100 mL of morpholine was heated at 225° C. for 60 mins. The mixture was cooled and precipitate filtered off, the filtrate was concentrated to give the 17 gram product as a brown oil.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationprecipitate filtered off
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-5420d8f6d19e4bcf92b4bfd6b98332b2
Source dataset
uspto-grants-2012_04
Patent number
US08148367B2

Reaction notes

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