反应详情

To a suspension of Lithium aluminium hydride (0.638 g, 0.0168 mol, 5.0 eq) in 20 mL THF at 0° C., add (R)-benzyl-2-((4-(4-fluoro-3-(trifluoromethyl)phenyl)-2-(piperidin-4-yl)-1H-imidazol-1-yl)methyl)piperidine-1-carboxylate in small portions (2.2 g, 0.0033 mol, 1.0 eq). Stir the reaction at RT for 4 hours. After completion, cool the reaction and quench with ice cold water followed by 10% NaOH solution and stir at RT and filter the resulting suspension through Celite®, wash the solid cake with EA. Dry the filtrate over anhydrous sodium sulfate and concentrate under reduced pressure to get 1.6 g of the title compound. (ES+): m/z 407 (M+H).

1. customthe reaction at RT for 4 hours
2. temperatureAfter completion, cool
3. customthe reaction
4. customquench with ice cold water
5. stirringstir at RT
6. filtrationfilter the resulting suspension through Celite®
7. washwash the solid cake with EA
8. dry with materialDry the filtrate over anhydrous sodium sulfate
9. concentrationconcentrate under reduced pressure