反应详情

温度

115 °C

2.5 g (15.14 mmol) of 4-methyl-1H-pyrazolo[3,4-b]pyridine-3,6-diol and 4.75 ml (39.2 mmol) of N,N-dimethylaniline were cautiously added to 60 ml of phosphorus oxychloride and the mixture was stirred at 115° C. for 5 h. The reaction mixture was concentrated and hydrolyzed with 30 g of ice. The product crystallized after some time. It was filtered off with suction and dried. Yield: 1.77 g (64%), M+H+: 184.1.

1. concentrationThe reaction mixture was concentrated and hydrolyzed with 30 g of ice
2. customThe product crystallized after some time
3. filtrationIt was filtered off with suction
4. customdried