HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 6-Chloro-1,4-dimethyl-3-oxo-1,3-dihydropyrazolo[3,4-b]pyridine-2-carboxylic acid (2-thiophen-2-ylethyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | HCID 86628145 | HCID 86628145 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-Chloro-1,4-dimethyl-3-oxo-1,3-dihydropyrazolo[3,4-b]pyridine-2-carboxylic acid (2-thiophen-2-ylethyl)amide | HCID 86628146 | — |
Reaction Steps
In analogy to example 2, 100 mg (0.297 mmol) of 6-chloro-4-methyl-3-oxo-1,3-dihydropyrazolo[3,4-b]pyridine-2-carboxylic acid (2-thiophen-2-ylethyl)amide were reacted with 22.2 μl of iodomethane in THF. Yield: 18 mg (77%), M+H+: 351.12.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148395B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-962039bc10cf4429a94c5ae781b0e09c |
| Source note | uspto-grants-2012_04 |