1-Isocyanato-1,2,3,4-tetrahydronaphthalene → HCID 86628150, compound

HRID 1685229Notes

Reaction equation

HRID 1685229 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]2[NH:8][N:9]=[C:10]([OH:11])[C:5]2=[C:4]([CH3:12])[CH:3]=1.[N:13]([CH:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:19][CH2:18][CH2:17]1)=[C:14]=[O:15]>C1COCC1.CN(C=O)C>[CH:16]1([NH:13][C:14]([N:9]2[C:10](=[O:11])[C:5]3[C:6](=[N:7][C:2]([Cl:1])=[CH:3][C:4]=3[CH3:12])[NH:8]2)=[O:15])[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:19][CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 162172391-Isocyanato-1,2,3,4-tetrahydronaphthaleneHCID 178426134HCID 178426134, compound

Product 1

HCID 86628150HCID 86628150, compound

Reagents, catalysts & solvents 1

HCID 21974620tetrahydrofuran N,N-dimethylformamideSolvent

Procedure

In analogy to example 1c, 200 mg (1.089 mmol) of 6-chloro-4-methyl-1H-pyrazolo-[3,4-b]pyridin-3-ol were reacted with 226.4 mg (1.2 mmol) of 1-isocyanato-1,2,3,4-tetrahydronaphthalene in THF/DMF at RT. Yield: 142 mg (37%), M+H+: 357.35.

Sources & evidence

ORD record
ord-191789458c5c4d58af815c4aed596ba6
Source dataset
uspto-grants-2012_04
Patent number
US08148395B2

Reaction notes

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