Potassium Bromide → 468740-89-8

HRID 1685295Notes

Reaction equation

Cl.[NH2:2][CH2:3][C@H:4]([C:6]1[CH:11]=[CH:10][C:9](OC)=[C:8]([Cl:14])[CH:7]=1)[OH:5].[K+].[Br-:16]>>[ClH:14].[NH2:2][CH2:3][C@H:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Br:16])[CH:7]=1)[OH:5]

Participants

Reactant 2

HCID 253877Potassium Bromide

HCID 67265736HCID 67265736, compound

Product 1

HCID 67265924468740-89-8

Procedure

The title material was prepared according to the general procedure outlined for the synthesis of (S)-2-amino-1-[3-chloro-4-methoxyphenyl]ethanol hydrochloride. LRMS [M+H]+ 217.9; IR (KBr, cm−1) 3025, 3443, 2891; 1H NMR (500 MHz, DMSO-d6) δ 7.93 (b s, 2H), 7.60 (s, 1H), 7.52 (d, 1H), 7.41 (s, 1H), 7.35 (d, J=7.7 Hz, 1H) 6.17 (s, 1H), 4.82 (m, 1H), 3.08 (ddd, J=2.6, 12.7, 9.6 Hz, 2H); 13C NMR (DMSO-d6, 75.5 MHz) δ 144.4, 130.5, 128.7, 125.0, 121.6, 68.3, 45.1.

Sources & evidence

ORD record: ord-2749c40ea2ea4eb985dc725988acb153
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08148400B2

Reaction notes

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