2-Aminothiazole → HCID 58217493, compound

HRID 1685603Notes

Reaction equation

[CH2:1]([N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([C:14]([OH:16])=O)=[N:6]1)[CH:2]([CH3:4])[CH3:3].[NH2:17][C:18]1[S:19][CH:20]=[CH:21][N:22]=1>>[S:19]1[CH:20]=[CH:21][N:22]=[C:18]1[NH:17][C:14]([C:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]([CH2:1][CH:2]([CH3:3])[CH3:4])[N:6]=1)=[O:16]

Participants

Reactant 2

HCID 21552-Aminothiazole

HCID 10560770HCID 10560770, compound

Product 1

HCID 58217493HCID 58217493, compoundYield 36.6%

Procedure

1-(Isobutyl)-indazole-3-carboxylic acid (340 mg) was obtained from methyl indazole-3-carboxylate (0.5 g, 2.84 mmol) and 1-iodo-2-methylpropane (0.33 mL, 2.84 mmol) following general procedures G and E. 1-(Isobutyl)-indazole-3-carboxylic acid thiazol-2-ylamide (66 mg) was prepared from 1-(isobutyl)-indazole-3-carboxylic acid (130 mg, 0.60 mmol) and 2-aminothiazole (150 mg, 1.5 mmol) following the general procedure H.

Sources & evidence

ORD record: ord-14603b0037ad4314907f7f3c05ebdc55
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08148413B2

Reaction notes

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