3,5-Dimethyl-4-hydroxybenzaldehyde → HCID 178426652, compound

HRID 1685704Notes

Reaction equation

HRID 1685704 reaction equation
[CH2:1]([C:3]1[CH:8]=[C:7]([C:9](=[NH:12])[NH:10][OH:11])[CH:6]=[C:5]([CH3:13])[C:4]=1[CH2:14][CH2:15][C:16]([OH:18])=[O:17])C.CC1C=C(C=C(C)C=1O)C=O>>[OH:11][NH:10][C:9]([C:7]1[CH:6]=[C:5]([CH3:13])[C:4]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[C:3]([CH3:1])[CH:8]=1)=[NH:12]

Participants

3

Reactant 2

HCID 752223,5-Dimethyl-4-hydroxybenzaldehydeHCID 178436623HCID 178436623, compound

Product 1

HCID 178426652HCID 178426652, compound

Procedure

The title compound is prepared in analogy to 3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid starting from 3,5-dimethyl-4-hydroxybenzaldehyde; LC-MS: tR=0.57 min, [M+1]+=237.02; 1H NMR (D6-DMSO): δ2.29 (s, 6H), 2.30-2.36 (m, 2H), 2.80-2.87 (m, 2H), 5.66 (s, 2H), 7.30 (s, 2H), 9.46 (s, 1H).

Sources & evidence

ORD record
ord-9e403cacf501447cae72d03a6ccb73bf
Source dataset
uspto-grants-2012_04
Patent number
US08148410B2

Reaction notes

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