4-Amino-3-chloro-5-methylbenzonitrile → HCID 178426663, compound

HRID 1685727Notes

Reaction equation

HRID 1685727 reaction equation
[NH2:1][C:2]1[C:9]([CH3:10])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[Cl:11].OC1C(C)=CC(C([NH:19][OH:20])=N)=CC=1C>>[NH2:1][C:2]1[C:9]([CH3:10])=[CH:8][C:5]([C:6]([NH:19][OH:20])=[NH:7])=[CH:4][C:3]=1[Cl:11]

Participants

3

Reactant 2

HCID 27353014-Amino-3-chloro-5-methylbenzonitrileHCID 178426654HCID 178426654, compound

Product 1

HCID 178426663HCID 178426663, compound

Procedure

The title compound is prepared from commercially available 4-amino-3-chloro-5-methylbenzonitrile in analogy to 4,N-dihydroxy-3,5-dimethyl-benzamidine; LC-MS: tR=0.50 min; [M+1]+=200.01; 1H NMR (D6-DMSO): δ 2.15 (s, 3H), 5.20 (s, 2H), 5.61 (s, 2H), 7.28 (s, 1H), 7.40 (s, 1H), 9.33 (s, 1H).

Sources & evidence

ORD record
ord-5dbcf2d75328445abdb8d91caf9f25f1
Source dataset
uspto-grants-2012_04
Patent number
US08148410B2

Reaction notes

Loading…