HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Formyl-2-thiophenecarboxylic Acid → 5-[3-(4-Hydroxy-3,5-dimethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-thiophene-2-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Formyl-2-thiophenecarboxylic Acid | HCID 818882 | — |
| Reactant | HCID 178426654 | HCID 178426654 | — |
| Product | 5-[3-(4-Hydroxy-3,5-dimethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-thiophene-2-carbaldehyde | HCID 136377325 | 15.5% |
Reaction Steps
The title compound (140 mg) is prepared from 5-formyl-2-thiophene carboxylic acid (468 mg, 3.0 mmol) and 4,N-dihydroxy-3,5-dimethyl-benzamidine (540 mg, 3.0 mmol) according to Method A; LC-MS: tR=1.01 min; [M+1]+=301.04; 1H NMR (D6-DMSO): δ2.24 (s, 6H), 7.64 (s, 2H), 8.17 (s, 2H), 8.99 (s, 1H), 10.06 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148410B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-fb5ecfa57f3448129744e995582fe621 |
| Source note | uspto-grants-2012_04 |