5-Formyl-4-methylthiophene-2-carboxylic acid → 3-{2-Ethyl-4-[5-(5-formyl-4-methyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenyl}-propionic acid ethyl ester

HRID 1685741노트

반응식

HRID 1685741 반응식
[CH:1]([C:3]1[S:7][C:6]([C:8]([OH:10])=O)=[CH:5][C:4]=1[CH3:11])=[O:2].[CH2:12]([O:14][C:15](=[O:31])[CH2:16][CH2:17][C:18]1[C:23]([CH3:24])=[CH:22][C:21]([C:25](=[NH:28])[NH:26]O)=[CH:20][C:19]=1[CH2:29][CH3:30])[CH3:13]>>[CH2:12]([O:14][C:15](=[O:31])[CH2:16][CH2:17][C:18]1[C:23]([CH3:24])=[CH:22][C:21]([C:25]2[N:28]=[C:8]([C:6]3[S:7][C:3]([CH:1]=[O:2])=[C:4]([CH3:11])[CH:5]=3)[O:10][N:26]=2)=[CH:20][C:19]=1[CH2:29][CH3:30])[CH3:13]

참가 물질

3

반응물 2

HCID 532126825-Formyl-4-methylthiophene-2-carboxylic acidHCID 178470908HCID 178470908, 화합물

생성물 1

HCID 866464453-{2-Ethyl-4-[5-(5-formyl-4-methyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenyl}-propionic acid ethyl ester

실험 절차

The title compound is prepared according to Method A starting from 5-formyl-4-methyl-thiophene-2-carboxylic acid and 3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid ethyl ester; LC-MS: tR=1.19 min; [M+1]+=413.15; 1H NMR (D6-DMSO) δ 1.20 (t, J=7.5 Hz, 3H), 1.22 (t, J=7.5 Hz, 3H), 2.40 (s, 3H), 2.44-2.50 (m, 2H), 2.65 (s, 3H), 2.73 (q, J=7.5 Hz, 2H), 2.93-3.00 (m, 2H), 4.11 (q, J=7.0 Hz, 2H), 7.71 (s, 1H), 7.72 (s, 1H), 8.07 (s, 1H), 10.17 (s, 1H).

출처 및 근거

ORD 기록
ord-855df44a6f5b4f26bbb5484e9f4c27f7
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148410B2

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