5-Formyl-4-methylthiophene-2-carboxylic acid → 3-{2-Ethyl-4-[5-(5-formyl-4-methyl-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenyl}-propionic acid ethyl ester

関与物質

反応手順

The title compound is prepared according to Method A starting from 5-formyl-4-methyl-thiophene-2-carboxylic acid and 3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid ethyl ester; LC-MS: tR=1.19 min; [M+1]+=413.15; 1H NMR (D6-DMSO) δ 1.20 (t, J=7.5 Hz, 3H), 1.22 (t, J=7.5 Hz, 3H), 2.40 (s, 3H), 2.44-2.50 (m, 2H), 2.65 (s, 3H), 2.73 (q, J=7.5 Hz, 2H), 2.93-3.00 (m, 2H), 4.11 (q, J=7.0 Hz, 2H), 7.71 (s, 1H), 7.72 (s, 1H), 8.07 (s, 1H), 10.17 (s, 1H).

情報源と証拠