反应详情

温度

0 °C

4-hydrazino-1H-pyridin-2-one (20.1 g, 161.0 mmol) prepared in Step 1 and 2-butanone (21.6 ml, 241.0 mmol) were added to ethanol (400 ml). The reaction mixture was refluxed under stirring for 4 hours and cooled to 0° C. The resulting precipitate was filtered and then washed with cooled ethanol to give the titled compound as a white solid. (Yield: 75.0%)

1. temperatureThe reaction mixture was refluxed
2. filtrationThe resulting precipitate was filtered
3. washwashed with cooled ethanol