Methyl Ethyl Ketone → 4-[2-(Butan-2-ylidene)hydrazinyl]pyridin-2(1H)-one

Participants

Reaction Conditions

Reaction Steps

4-hydrazino-1H-pyridin-2-one (20.1 g, 161.0 mmol) prepared in Step 1 and 2-butanone (21.6 ml, 241.0 mmol) were added to ethanol (400 ml). The reaction mixture was refluxed under stirring for 4 hours and cooled to 0° C. The resulting precipitate was filtered and then washed with cooled ethanol to give the titled compound as a white solid. (Yield: 75.0%)

Provenance & Evidence