4-Fluorobenzyl bromide → HCID 66686584, compound

HRID 1686029Notes

Reaction equation

HRID 1686029 reaction equation
[CH3:1][N:2]1[C:10]2[CH:9]=[CH:8][N:7]=[C:6](NCC3C=CC(F)=CC=3)[C:5]=2[C:4]([CH3:20])=[C:3]1[CH3:21].[ClH:22].CN1[C:32]2[CH:31]=[CH:30]N=[C:28]([NH:33][CH2:34][C:35]3[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=3)[C:27]=2[C:26]([CH3:42])=C1C.C(=O)(O)[O-].[Na+].[F:49]C1C=CC(CBr)=CC=1>>[ClH:22].[F:49][C:30]1[CH:42]=[CH:26][C:27]([CH2:28][N:33]([C:9]2[C:10]3[N:2]([CH3:1])[C:3]([CH3:21])=[C:4]([CH3:20])[C:5]=3[CH:6]=[N:7][CH:8]=2)[CH2:34][C:35]2[CH:36]=[CH:37][C:38]([F:41])=[CH:39][CH:40]=2)=[CH:32][CH:31]=1

Participants

5

Reactant 4

HCID 680214-Fluorobenzyl bromideHCID 516892Sodium BicarbonateHCID 11666896HCID 11666896, compoundHCID 11666897HCID 11666897, compound

Product 1

HCID 66686584HCID 66686584, compoundYield 49.9%

Procedure

In accordance with the same procedures as in Example 47, except for using 1,2,3-trimethyl-4-(4-fluorobenzylamino)-1H-pyrrolo[3,2-c]pyridine obtained by treating the compound of Example 34 with a saturated sodium bicarbonate solution and 4-fluorobenzyl bromide, the titled compound was obtained as a white solid. (Yield: 49.9%)

Workup

  1. customobtained

Sources & evidence

ORD record
ord-ab176245d18e4e4ebbf5f4e9b7bad4e5
Source dataset
uspto-grants-2012_04
Patent number
US08148529B2

Reaction notes

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