Aluminium lithium hydride → HCID 25017919, compound

HRID 1686051Notes

Reaction equation

HRID 1686051 reaction equation
[F:1][C:2]1[C:10]([O:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH2:25][C:26]4([C:29]([N:31]([CH3:33])[CH3:32])=O)[CH2:28][CH2:27]4)=[C:19]([O:22][CH3:23])[CH:20]=3)[N:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:34])[NH:6]2.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[F:1][C:2]1[C:10]([O:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH2:25][C:26]4([CH2:29][N:31]([CH3:32])[CH3:33])[CH2:27][CH2:28]4)=[C:19]([O:22][CH3:23])[CH:20]=3)[N:15]=[CH:14][CH:13]=2)=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH3:34])[NH:6]2

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 25017920HCID 25017920, compound

Product 1

HCID 25017919HCID 25017919, compoundYield 64.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product of Example 11 (80 mg) was stirred with LAH (2 eq) in THF (10 ml) at 0° C. for 10 minutes. The reaction was refluxed for 45 minutes and quenched with water. The solution was evaporated and purified with silica gel column to give the titled product (50 mg). Mass: (M+1), 450

Workup

  1. temperatureThe reaction was refluxed for 45 minutes
  2. customquenched with water
  3. customThe solution was evaporated
  4. custompurified with silica gel column

Sources & evidence

ORD record
ord-8639eddc42ac453895be4b661eef19ad
Source dataset
uspto-grants-2012_04
Patent number
US08148532B2

Reaction notes

Loading…