反应详情

A solution of 3,3′-[2-(2-bromophenyl)ethane-1,1-diyl]dipyridine (30 mg, 0.05 mmol), 3-(dihydroxyboryl)benzoic acid (14 mg, 0.08 mmol), and dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct (5 mg, 0.006 mmol) in THF (2.0 mL) was treated aqueous Cs2CO3 (1.0 mL of a 1 M solution, 1.0 mmol) and sealed in a 5 mL microwave reaction tube. The mixture was irradiated at 160° C. for 10 min, cooled, and the phases separated. The organic phase was blown down under a stream of N2 and purified by reverse phase chromatography to provide the title compound. ESI+MS: 381.1 [M+H]+.

1. customsealed in a 5 mL microwave reaction tube
2. customThe mixture was irradiated at 160° C. for 10 min
3. temperaturecooled
4. customthe phases separated
5. custompurified by reverse phase chromatography