Hexane → HCID 86627410, compound

HRID 1686146Notes

Reaction equation

HRID 1686146 reaction equation
[Br:1][C:2]1[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=1[CH2:4][O:5][C:6]1[CH:13]=[C:12]([O:14]C2CCCCO2)[CH:11]=[CH:10][C:7]=1[CH:8]=[O:9].CCCCCC>CCO>[Br:1][C:2]1[CH:24]=[CH:23][CH:22]=[CH:21][C:3]=1[CH2:4][O:5][C:6]1[CH:13]=[C:12]([OH:14])[CH:11]=[CH:10][C:7]=1[CH:8]=[O:9]

Participants

4

Reactant 2

HCID 8058HexaneHCID 86627411HCID 86627411, compound

Product 1

HCID 86627410HCID 86627410, compoundYield 109.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(2-Bromobenzyloxy)-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde (4.4 g) obtained in step 1) was dissolved in a mixture of 10% HCL (30 mL) and EtOH (20 mL), followed by stirring for 1 hour and extraction with ethyl acetate. The extract was dried over MgSO4 and concentrated. The solid thus formed was cleansed with hexane to afford the object compound (3.78 g, 91%).

Workup

  1. extractionextraction with ethyl acetate
  2. dry with materialThe extract was dried over MgSO4
  3. concentrationconcentrated
  4. customThe solid thus formed

Sources & evidence

ORD record
ord-6d31dec95614404097dfb4c2e156e607
Source dataset
uspto-grants-2012_04
Patent number
US08148541B2

Reaction notes

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