Trifluoroacetic acid → HCID 86627414, compound

HRID 1686150Notes

Reaction equation

HRID 1686150 reaction equation
[Br:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][CH2:7][CH2:8][N:9](C)[C:10](=O)OC(C)(C)C)=[C:4]([CH:20]=[O:21])[CH:3]=1.[C:22]([OH:28])([C:24]([F:27])([F:26])[F:25])=[O:23]>C(Cl)Cl>[F:25][C:24]([F:27])([F:26])[C:22]([OH:28])=[O:23].[Br:1][C:2]1[CH:19]=[CH:18][C:5]([O:6][CH2:7][CH2:8][NH:9][CH3:10])=[C:4]([CH:3]=1)[CH:20]=[O:21]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86627416HCID 86627416, compound

Product 1

HCID 86627414HCID 86627414, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of t-butyl 2-(4-bromo-2-formylphenoxy)ethylmethylcarbamate (1.26 g, 3.52 mmol) in CH2Cl2 (50 ml) was added TFA (4.01 g, 2.71 mmol 35.17 mmol) at 0° C., followed by stirring for 9 hours. Thereafter, the reaction solution was concentrated in a vacuum and completely dried to afford the object compound (dark brown oil, suitable amount).

Workup

  1. concentrationThereafter, the reaction solution was concentrated in a vacuum
  2. customcompletely dried
  3. customto afford the object compound (dark brown oil, suitable amount)

Sources & evidence

ORD record
ord-5297169348234e6fad70b35d31fc3b9d
Source dataset
uspto-grants-2012_04
Patent number
US08148541B2

Reaction notes

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