HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 4-Chloro-3-hydroxyphenylacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 2-(4-Chloro-3-methoxyphenyl)acetic acid | HCID 20497655 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-Chloro-3-hydroxyphenylacetic acid | HCID 3017183 | 93.4% |
Reaction Steps
The product from step (ii) (12.2 g), HBr (48% aq.) and acetic acid (10 ml) were charged to a flask and heated at reflux for 24 h, cooled then evaporated under reduced pressure. The residue was triturated with ether/isohexane, and then filtered to give the subtitle compound (10.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148572B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-c47ae56e467746e6a83d5b08acb045ab |
| Source note | uspto-grants-2012_04 |