反应详情

The product from step (ii) (12.2 g), HBr (48% aq.) and acetic acid (10 ml) were charged to a flask and heated at reflux for 24 h, cooled then evaporated under reduced pressure. The residue was triturated with ether/isohexane, and then filtered to give the subtitle compound (10.6 g).

1. temperatureheated
2. temperatureat reflux for 24 h
3. temperaturecooled
4. customthen evaporated under reduced pressure
5. customThe residue was triturated with ether/isohexane
6. filtrationfiltered