Acetyl chloride → HCID 58785142, compound

HRID 1686376Notes

Reaction equation

HRID 1686376 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[OH:12].[C:13](Cl)(=O)[CH3:14]>C(O)C>[CH2:13]([O:10][C:9](=[O:11])[CH2:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([OH:12])[CH:4]=1)[CH3:14]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 30171834-Chloro-3-hydroxyphenylacetic acid

Product 1

HCID 58785142HCID 58785142, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product of step (iii) (4 g) was added to a solution of acetyl chloride (10 ml) in ethanol (40 ml). The mixture was stirred for 1 h at RT then evaporated under reduced pressure. The residue was purified by flash column chromatography (eluent 2:1 isohexane/EtOAc) to give the subtitle compound (4.4 g).

Workup

  1. customthen evaporated under reduced pressure
  2. customThe residue was purified by flash column chromatography (eluent 2:1 isohexane/EtOAc)

Sources & evidence

ORD record
ord-171352a18fa540cfa2f2fa0e4d8f858d
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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