反应详情

The product of step (i) (0.5 g) was added to a solution of nBuLi (1.75 ml, 1.6 M in THF) and diisopropylamine (0.4 ml) in THF (10 ml) at −78° C. and stirred for 1 h, then methyl iodide (0.18 ml) was added, stirred for 1 h at −78° C. then at room temperature for 1 h and quenched with water. The product was extracted with ether, dried (MgSO4) and evaporated under reduced pressure. The residue was purified by flash column chromatography (eluent 1:1 isohexane/ether) to give the subtitle compound (0.21 g).

1. stirringstirred for 1 h at −78° C.
2. waitat room temperature for 1 h
3. customquenched with water
4. extractionThe product was extracted with ether
5. dry with materialdried (MgSO4)
6. customevaporated under reduced pressure
7. customThe residue was purified by flash column chromatography (eluent 1:1 isohexane/ether)