Hydrogen Bromide → Methyl 2-(4-chloro-3-hydroxyphenyl)propanoate

HRID 1686383Notes

Reaction equation

HRID 1686383 reaction equation
Br.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:14])[C:10]([O:12][CH3:13])=[O:11])=[CH:5][C:4]=1[O:15]C>C(O)(=O)C>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:14])[C:10]([O:12][CH3:13])=[O:11])=[CH:5][C:4]=1[OH:15]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 67266387Methyl 2-(4-chloro-3-methoxyphenyl)propanoate

Product 1

HCID 67266160Methyl 2-(4-chloro-3-hydroxyphenyl)propanoate

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

48% aqueous HBr (10 ml) was added to the product of step (ii) (0.21 g) in acetic acid (10 ml) and heated at 100° C. for 10 h.

Sources & evidence

ORD record
ord-08b907b200b04506b83085a08c1e6f4e
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

Loading…