1,2-Difluoro-4-(methylsulfonyl)benzene → {4-Chloro-3-[2-fluoro-4-(methylsulfonyl)phenoxy]phenyl}acetic acid

HRID 1686387Notes

Reaction equation

HRID 1686387 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8](F)=[C:7]([F:12])[CH:6]=1)(=[O:4])=[O:3].[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][C:21]([OH:23])=[O:22])=[CH:16][C:15]=1[OH:24]>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][C:21]([OH:23])=[O:22])=[CH:16][C:15]=1[O:24][C:8]1[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:6][C:7]=1[F:12]

Participants

3

Reactant 2

HCID 27827431,2-Difluoro-4-(methylsulfonyl)benzeneHCID 30171834-Chloro-3-hydroxyphenylacetic acid

Product 1

HCID 57791958{4-Chloro-3-[2-fluoro-4-(methylsulfonyl)phenoxy]phenyl}acetic acid

Procedure

The title compound was prepared by the method of example 2 step (iii) using 3,4-difluorophenyl methyl sulfone and the product of example 1 step (iii).

Sources & evidence

ORD record
ord-54404c4e07054a6cb517702f8e4f89d9
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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