HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 2-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Methyl 2-[3-methoxy-5-(trifluoromethyl)phenyl]propanoate | HCID 66734169 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acid | HCID 66734097 | 70% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
The product from step (ii) (0.8 g) was dissolved in glacial acetic acid (20 ml) and treated with 48% aqueous HBr (20 ml). The mixture was heated at 100° C. for 16 h. The mixture was cooled and diluted with 2M NaOH, extracted with ethyl acetate, dried (MgSO4) and evaporated under reduced pressure to give an oil, which was purified by RPHPLC to give a colourless oil (0.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08148572B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-9b82a0e8a97c492b9a6bc35743ac3cbc |
| Source note | uspto-grants-2012_04 |