反应详情

温度

100 °C

The product from step (ii) (0.8 g) was dissolved in glacial acetic acid (20 ml) and treated with 48% aqueous HBr (20 ml). The mixture was heated at 100° C. for 16 h. The mixture was cooled and diluted with 2M NaOH, extracted with ethyl acetate, dried (MgSO4) and evaporated under reduced pressure to give an oil, which was purified by RPHPLC to give a colourless oil (0.5 g).

1. temperatureThe mixture was cooled
2. extractionextracted with ethyl acetate
3. dry with materialdried (MgSO4)
4. customevaporated under reduced pressure
5. customto give an oil, which
6. customwas purified by RPHPLC