2-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acid → 2-[3-[2-Chloro-4-(phenylsulfonyl)phenoxy]-5-(trifluoromethyl)phenyl]propanoic acid

HRID 1686426Notes

Reaction equation

HRID 1686426 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[C:17]1([S:23]([C:26]2[CH:31]=[CH:30][C:29](F)=[C:28]([Cl:33])[CH:27]=2)(=[O:25])=[O:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[Cl:33][C:28]1[CH:27]=[C:26]([S:23]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)(=[O:24])=[O:25])[CH:31]=[CH:30][C:29]=1[O:1][C:2]1[CH:3]=[C:4]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:7]=1

Participants

3

Reactant 2

HCID 667340972-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acidHCID 689525093-Chloro-4-fluorophenyl phenyl sulfone

Product 1

HCID 161235372-[3-[2-Chloro-4-(phenylsulfonyl)phenoxy]-5-(trifluoromethyl)phenyl]propanoic acid

Procedure

The title compound was prepared as described in example 2 step (iii) but instead using the product from example 50 step (iii) and the product from example 29 step (i).

Sources & evidence

ORD record
ord-2344bd33b2444d9f971145d46f687239
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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