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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1686426Generated: October 27, 2026

2-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acid → 2-[3-[2-Chloro-4-(phenylsulfonyl)phenoxy]-5-(trifluoromethyl)phenyl]propanoic acid

https://huagongshe.com/reaction/1686426

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acidHCID 66734097—
Reactant3-Chloro-4-fluorophenyl phenyl sulfoneHCID 68952509—
Product2-[3-[2-Chloro-4-(phenylsulfonyl)phenoxy]-5-(trifluoromethyl)phenyl]propanoic acidHCID 16123537—

Reaction Steps

The title compound was prepared as described in example 2 step (iii) but instead using the product from example 50 step (iii) and the product from example 29 step (i).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08148572B2
Source datasetuspto-grants-2012_04
ORD IDord-2344bd33b2444d9f971145d46f687239
Source noteuspto-grants-2012_04