2-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acid → 2-[3-{2-Chloro-4-[(4-fluorobenzyl)sulfonyl]phenoxy}-5-(trifluoromethyl)phenyl]propanoic acid

HRID 1686427Notes

Reaction equation

HRID 1686427 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[Cl:17][C:18]1[CH:23]=[C:22]([S:24]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=2)(=[O:26])=[O:25])[CH:21]=[CH:20][C:19]=1F>>[Cl:17][C:18]1[CH:23]=[C:22]([S:24]([CH2:27][C:28]2[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=2)(=[O:26])=[O:25])[CH:21]=[CH:20][C:19]=1[O:1][C:2]1[CH:3]=[C:4]([CH:12]([CH3:16])[C:13]([OH:15])=[O:14])[CH:5]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:7]=1

Participants

3

Reactant 2

HCID 667340972-[3-Hydroxy-5-(trifluoromethyl)phenyl]propanoic acidHCID 689534292-Chloro-1-fluoro-4-[(4-fluorobenzyl)sulfonyl]benzene

Product 1

HCID 161235382-[3-{2-Chloro-4-[(4-fluorobenzyl)sulfonyl]phenoxy}-5-(trifluoromethyl)phenyl]propanoic acid

Procedure

The title compound was prepared as described in example 2 step (iii) but instead using the product from example 50 step (iii) and the product from example 34 step (i).

Sources & evidence

ORD record
ord-ef5c8e05d8c64f6bac6446f5a515a184
Source dataset
uspto-grants-2012_04
Patent number
US08148572B2

Reaction notes

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